Topics in carbohydrate stereochemistry
نویسندگان
چکیده
منابع مشابه
Molecular dynamics simulation of monoalkyl glycoside micelles in aqueous solution: influence of carbohydrate headgroup stereochemistry.
Comparative molecular dynamics simulations of n-octyl-beta-D-galactopyranoside (beta-C8Gal) and n-octyl-beta-D-glucopyranoside (beta-C8Glc) micelles in aqueous solution have been performed to explore the influence of carbohydrate stereochemistry on glycolipid properties at the atomic level. In particular, we explore the hypothesis that differences in T(m) and T(c) for beta-C8Gal and beta-C8Glc ...
متن کاملCoronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation.
Hemagglutinin-esterases (HEs) are bimodular envelope proteins of orthomyxoviruses, toroviruses, and coronaviruses with a carbohydrate-binding "lectin" domain appended to a receptor-destroying sialate-O-acetylesterase ("esterase"). In concert, these domains facilitate dynamic virion attachment to cell-surface sialoglycans. Most HEs (type I) target 9-O-acetylated sialic acids (9-O-Ac-Sias), but o...
متن کاملMechanistic inferences from stereochemistry.
I am still impressed that the textbook language of organic chemistry is so successful in explaining the reactions that we find in nature. Thismight not have been anticipated because we find that biological reactions are invariably stereospecific whereas nonbiological reactions are invariably not. This realization came to light about 150 years ago when Pasteur found that only half of chemically ...
متن کاملDictionary of Protein Stereochemistry
A computer-readable dictionary for protein structure refinement is presented. The dictionary is based on the set of interatomic bonds and bond angles previously derived from small-molecule structures by Engh & Huber [Acta Cryst. (1991), A47, 392-400]. The internal inconsistency of the set is discussed. Some preliminary results derived from several protein structures refined at atomic resolution...
متن کاملTopics in Representation Theory: Other Topics
• Topology of G/T : Flag manifolds G/T have cohomology only in even degrees, with Euler characteristic the degree of the Weyl group. The Euler characteristic can be calculated by a Lefschetz fixed point argument (see Adams [1], pgs. 90-92 for this). Identifying the flag manifold with a co-adjoint orbit, there is a Morse theory calulation of the cohomology that goes back to Bott, for an outline ...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 1987
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac198759111521